Bio-Compatible Restorations

Biocompatibility refers to the ability of a biomaterial to perform its desired function with respect to a medical therapy, without eliciting any Inflammatory - Allergic – Immune – Toxic – Mutagen – Carcinogenic effects in the recipient or beneficiary of that therapy, but generating the most appropriate beneficial cellular or tissue response in that specific situation, and optimizing the clinically relevant performance of that therapy.

Biological dentistry emphasizes the use of most bio-compatible materials available for dental treatments and dental restorations because of the following:

  • Dental fillings and their potential allergic effect.
  • Toxicology and Allergology of dental plastic materials.
  • Dental materials should not only look good and last a long time, they should also be well tolerated.

Questions about their toxicology and biocompatibility have raised a growing interest. Monomer and co-monomer compounds are used in dental medicine, in composites and dentine adhesives. It is possible for such compounds to be released from these materials and end up in the human body through resorption. One important aspect in the evaluation of toxicology in the determination of the resorption, metabolism, and elimination of a substance in an organism. Only resorbed substances can cause damage. Studies have shown that the (co)monomers hydroxyethyl methacrylate ( HEMA) triethylene glycol dimethacrylate ( TEGDMA) and bisphenol glycidyl methacrylate( BisGMA) released from composites and swallowed are completely resorbed and broken down to CO2 in the body.

It has also been shown that intermediates produced during the metabolism can have strong toxic effects themselves - leading to "poisoning". During the decomposition of HEMA and TEGDMA in human liver microsomes, the formation of an epoxy intermediate, 2,3-epoxymethacrylic acid, has been detected. Epoxy compounds are considered carcinogenic and mutagenic. For a scientifically supported risk analysis, it is important to know how much of a substance will be released by a material, how much is actually absorbed by the organism, and at what level do health problems start manifesting in the organism.

In the past 10 years, a growing number of patients have shown increased manifestations of adverse effects ( lichenoid reaction, asthma, eczema) after dental restoration. The trigger of such reactions has now been conclusively identified as methacrylates HEMA and TEGDMA, which are commonly used in dental medicine.

In continuous research by SAREMCO laboratories, the release rate of such compounds was determined for many of the commercially available composites and adhesives and the world's largest database of its kind was established. In collaboration with the clinics at Ludwig Maximilians University Munich, allergy tests were developed to prove the possible presence of any existing allergies to substances from dental materials.

In collaboration with the clinics at Ludwig Maximilians University Munich, allergy tests were developed to prove the possible presence of any existing allergies to substances from dental materials.


Selection of the best tolerated dental materials before a dental restoration

Ludwig Maximilians University Munich has recently established the International Advisory Centre for the tolerance of Dental Materials ( Today, after allergy testing and using the world's largest available database it is possible to select optimal, best-tolerated fillings material for a live patient before a planned dental restoration.
Patients with known allergies and intolerance reactions can consult this dental toxicology advisory centre at LMU Munich before undergoing dental restoration. At the centre it can also be determined whether the patient currently has dental material in his or her mouth that is responsible for the symptoms. If that is the case, the patient should have the material removed as quickly as possible and replaced by the recommended, best tolerated dental material. Matrix Technology At Dr. Roze and Associates, we use SAREMCO dental material, specifically the Geen line restoration system. The dental materials are free from the monomers TEGDMA and HEMA, and does not replace these substances by adding other monomers of low molecular weight. Moreover, the dental material is free from urethane-methacrylate ( UDMA), because UDMA always contains HEMA, albeit in traces. Given the toxicology and Allergology of TEGDMA and HEMA described in the literature, the removal of these substances from dental materials has a preventive effect in toxicological and allergological terms, and thus provides a benefit.

How does an unbalanced oral microbiome affect your child’s teeth? Some harmful bacteria, such as Streptococcus mutans, live in the sticky biofilm on tooth surfaces. As good bacteria are depleted, S. mutans numbers increase, feeding on sugar in the diet to produce acids that break down healthy tooth enamel.


Book An Appointment